Risk Factors for Alzheimer's

By Mayo Clinic staff
Age Increasing age is the greatest known risk factor for Alzheimer's. Alzheimer's is not a part of normal aging, but your risk increases greatly as you grow older. After you reach age 65, your risk of developing the disease doubles about every five years. Nearly half of those over age 85 have Alzheimer's. People with rare genetic changes that guarantee they'll develop Alzheimer's often begin experiencing symptoms in their 40s or 50s.
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Family history & genetics Your risk of developing Alzheimer's appears to be somewhat higher if a first-degree relative, like a parent, sibling or child, has the disease. Scientists have identified rare changes, or mutations, in 3 genes that guarantee a person who inherits them will develop Alzheimer's. But these mutations account for less than 5% of Alzheimer's disease. Most genetic mechanisms of Alzheimer's among families remain largely unexplained. The strongest risk gene researchers have found so far is called apolipoprotein e4 or APOE-e4. Other risk genes have been identified but not conclusively confirmed. Sex Women may be more likely than are men to develop Alzheimer's disease, partly because they tend to live longer. Mild cognitive impairment People with mild cognitive impairment have memory problems or other symptoms of cognitive decline that are worse than might be expected for their age, but not severe enough to be diagnosed as dementia. Those with MCI have an increased risk of later developing dementia.
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Lifestyle & heart health There's no lifestyle factor that's been conclusively shown to reduce your risk of Alzheimer's disease.  However, some evidence suggests that the same factors that put you at risk of heart disease may also increase the chance that you'll develop Alzheimer's. Examples include: Lack of exercise Smoking High blood pressure High cholesterol Poorly controlled diabetes These risk factors are, also, linked to vascular dementia, a type of cognitive decline caused by damaged blood vessels in the brain. Many people with cognitive decline have brain changes characteristic of both Alzheimer's disease & vascular dementia. Some researchers think that each condition helps fuel the damage caused by the other. Working with your health care team on a plan to control these factors will help protect your heart, & may, also, help reduce your risk of dementia.
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Lifelong learning & social engagement Studies have found an association between lifelong involvement in mentally & socially stimulating activities & reduced risk of Alzheimer's disease. Factors that may reduce your risk of Alzheimer's include: Higher levels of formal education A stimulating job Mentally challenging leisure activities, such as reading, playing games or playing a musical instrument Frequent social interactions Scientists can't yet explain this link. One theory is that using your brain develops more cell-to-cell connections, which protects your brain against the impact of Alzheimer-related changes. Another theory is that it may be harder to measure cognitive decline in people who exercise their minds frequently or who have more education. Still another explanation is that people with Alzheimer's disease may be less inclined to seek out stimulating activities years before their disease can be diagnosed.